"The theft sparked a major search operation involving sniffer dogs and dozens of police officers.
Italian authorities said they believe the theft was commissioned, as thieves stole only the relic and left many other valuables behind at the church.
Only three of John Paul II's relics contain his blood and they are all considered of great religious value.
As the late pontiff's blood would be difficult to sell, Italian police said it is possible the thieves may plan to use it for satanic rites."